Download Advances in Viral Genomes Research by John A. Borrelli, Ylenia D. Giannini PDF

By John A. Borrelli, Ylenia D. Giannini

ISBN-10: 1628087234

ISBN-13: 9781628087239

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Later on, the amplicon vector expressing BDNF was used in mice to infect damaged spiral Amplicon Vectors for Gene Transfer 35 ganglion. Four weeks post-infection, stable production of BDNF was observed; and it supported the survival of auditory neurons by preventing their loss due to trophic factor deprivation-induced apoptosis [149]. In addition, the use of amplicons expressing BDNF promoted neuronal survival up to the same maximal level seen by adding exogenous BDNF, in a model of avian cochlear neuron cultures [150].

Amplicons expressing neurotrophin-3 (NT-3) were also used in murine cochlear explants model. After infection, the cochlear explants were exposed to cisplatin to induce destruction of hair cells and neurons in the auditory system. This toxicity, defined as ototoxicity, is a major dose-limiting side effect of cisplatin chemotherapy for cancer patients. Amplicon-mediated NT-3 transduction was shown to attenuate the ototoxic action of cisplatin, demonstrating the potency of NT-3 in protecting spiral ganglion neurons from degeneration [151].

52535. 42 Matias E. Melendez, Alejandra I. Aguirre, Maria V. Baez et al. , HSV-1 amplicon vectors that direct the in situ production of foot-and-mouth disease virus antigens in mammalian cells can be used for genetic immunization. Vaccine, 2010. 28(46): p. 736372. , Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. J Virol, 2002. 76(11): p. 5565-80. , Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming.

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