By R. Guevara-Gonzalez
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Deletions in targeted regions of AflJ, also prevented observable binding. AflJ stimulated the accumulation of AF and precursor metabolites in cultures when the transformant also contained a functional aflR gene. , 1995). Based on these results AflJ was classified as an AflR coactivator. , 2007). AflJ’s transcription was regulated by AflR in A. flavus and A. parasiticus. An AflR-binding site near the 26 Aflatoxins – Biochemistry and Molecular Biology translational start site of aflJ (Fig. 2) may mediate this activation.
2008b). VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism, Science 320, 1504-1506. L. T. (2008). Adr1 and Cat8 mediate coactivator recruitment and chromatin remodeling at glucose-regulated genes, PLoS One 3, e1436. W. P. (2004). , Eukaryot. Cell. 3, 527-535. P. P. (2006). Secondary metabolic gene cluster silencing in Aspergillus nidulans, Mol. Microbiol. 61, 1636-1645. Brodhagen, M. P. (2006). Signaling pathways connecting mycotoxin production and sporulation, Mol Plant Pathology 7, 285-301.